ISSN 2734-245X
 
2026, Vol: 5, Issue: 2
5 / 2Current Issue Online FirstArchiveAims and ScopeMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

COVER LETTER TEMPLATE
FIRST PAGE FILE

Original Article
Online Published: 12 Feb 2023
 

doi: 10.5455/CRJMED.143535


Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria

Ubong A. Udoh, Ernest A. Ochang, Emmanuel E. Effa, Kenneth I. Onyedibe, Usang E. Usang, Onyebuchi E. Osakwe, Joseph E. Asuquo.


Abstract
Background/Objective: Tigecycline belongs to the glycylcycline class of antibiotics with in-vitroactivity against most gram-positive bacteria, including multidrug-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) is one of such pathogen, which has been associated with community and hospital-acquired infections. Tigecycline is considered to be a newer treatment option for emerging multidrug-resistant bacteria. This study aims to determine the in-vitro activity of tigecycline against community and hospital-acquired MRSA isolated from infected traumatic wounds in Cross River State.
Material and Methods: A total of 60 MRSA were isolated from wound samples, 30 each from the community and hospital settings. These were tested for tigecycline susceptibility by the E-test method. Detection of methicillin resistance was performed using cefoxitin (30µg) disk. All strains were identified according to standard bacteriological methods.
Results: Of the 60 isolates, 55 (91.7%) were sensitive to tigecycline with MIC50 and MIC90 values of 0.25 and 0.5μg/ml, respectively. Twenty-seven (90.0%) of the 30 community-acquired isolates were susceptible to tigecycline, while 28 (93.3%) of the 30 hospital-acquired isolates were susceptible.
Conclusions: Tigecycline showed excellent in-vitro activity against MRSA wound isolates and, therefore may be a drug of choice for empirical therapy of skin and soft tissue infections in areas where MRSA is prevalent.

Key words: MRSA, Tigecycline, MIC, Antimicrobial susceptibility, E-Test


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ubong A. Udoh
Articles by Ernest A. Ochang
Articles by Emmanuel E. Effa
Articles by Kenneth I. Onyedibe
Articles by Usang E. Usang
Articles by Onyebuchi E. Osakwe
Articles by Joseph E. Asuquo
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Udoh UA, Ochang EA, Effa EE, Onyedibe KI, Usang UE, Osakwe OE, Asuquo JE. Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria. crjmed. 2017; 1(1): 18-25.

doi:10.5455/CRJMED.143535

Web Style

Udoh UA, Ochang EA, Effa EE, Onyedibe KI, Usang UE, Osakwe OE, Asuquo JE. Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria. https://www.crjmed.com/?mno=143535 [Access: June 28, 2026].

doi:10.5455/CRJMED.143535

AMA (American Medical Association) Style

Udoh UA, Ochang EA, Effa EE, Onyedibe KI, Usang UE, Osakwe OE, Asuquo JE. Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria. crjmed. 2017; 1(1): 18-25.


doi:10.5455/CRJMED.143535

Vancouver/ICMJE Style

Udoh UA, Ochang EA, Effa EE, Onyedibe KI, Usang UE, Osakwe OE, Asuquo JE. Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria. crjmed. (2017), [cited June 28, 2026]; 1(1): 18-25.


doi:10.5455/CRJMED.143535

Harvard Style

Udoh, U. A., Ochang, . E. A., Effa, . E. E., Onyedibe, . K. I., Usang, . U. E., Osakwe, . O. E. & Asuquo, . J. E. (2017) Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria. crjmed, 1 (1), 18-25.


doi:10.5455/CRJMED.143535

Turabian Style

Udoh, Ubong A., Ernest A. Ochang, Emmanuel E. Effa, Kenneth I. Onyedibe, Usang E. Usang, Onyebuchi E. Osakwe, and Joseph E. Asuquo. 2017. Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria. Cross River Journal of Medicine, 1 (1), 18-25.


doi:10.5455/CRJMED.143535

Chicago Style

Udoh, Ubong A., Ernest A. Ochang, Emmanuel E. Effa, Kenneth I. Onyedibe, Usang E. Usang, Onyebuchi E. Osakwe, and Joseph E. Asuquo. "Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria." Cross River Journal of Medicine 1 (2017), 18-25.


doi:10.5455/CRJMED.143535

MLA (The Modern Language Association) Style

Udoh, Ubong A., Ernest A. Ochang, Emmanuel E. Effa, Kenneth I. Onyedibe, Usang E. Usang, Onyebuchi E. Osakwe, and Joseph E. Asuquo. "Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria." Cross River Journal of Medicine 1.1 (2017), 18-25. Print.


doi:10.5455/CRJMED.143535

APA (American Psychological Association) Style

Udoh, U. A., Ochang, . E. A., Effa, . E. E., Onyedibe, . K. I., Usang, . U. E., Osakwe, . O. E. & Asuquo, . J. E. (2017) Evaluation of tigecycline activity on wound isolates of methicillinresistant Staphylococcus aureus from hospital and communityacquired infections in Cross River State, Nigeria. Cross River Journal of Medicine, 1 (1), 18-25.


doi:10.5455/CRJMED.143535

Author LoginReviewer LoginPeer Review PolicyPublication Ethics and Publication Malpractice StatementAdvertising Policy

About Cross River Journal of Medicine

About the JournalThe Cross River Journal of Medicine (CRJMED) is a peer-reviewed international journal published by the Nigerian Medical Association, C ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


For all inquiries, send an email to
Dr Bernard Akpu
Email: crjmed23@gmail.com